Risk of Miscarriage Increased with Antidepressants and Pain Killers

Women with PCOS have poorer pregnancy outcomes than other women.

One thing you can do for a better outcome is carefully review your use of pharmaceutical drugs while pregnant.

Free PCOS Newsletter

First Name
Email *

A Canadian study of 5,124 women has revealed that women who take either antidepressants or NSAIDs (non-steroidal anti-inflammatory drugs) while pregnant have a significantly higher rate of miscarriage.

The most commonly used antidepressants were SSRIs. Among these, paroxetine (Paxil) and venlafaxine (Effexor) were associated with a 51% increased risk of spontaneous abortion.

The risk of aborted pregnancy also increased with higher daily doses of these drugs. In addition, the researchers noted that using a combination of different antidepressants doubled the risk.

Unfortunately, antidepressant use is common during pregnancy, with up to 3.7% of women taking the drugs during the first trimester.

The study indicated that the drugs, rather than the mothers' depression and anxiety, were associated with an increased risk for miscarriage.

NSAIDS Also a Risk

Women taking NSAIDs during the early stages of pregnancy had 2.4 times the risk of miscarriage compared to women who did not take NSAIDs in this study.

Individual drugs have different risks. Diclofenac tripled the risk; naproxen (Aleve) had a 2.6-times increased risk, and ibuprofen (Advil, Motrin) doubled the risk. Combinations of drugs were associated with a 2.6-times increased risk.

We all have little aches and pains at times. This is usually caused by inflammation. You can actually reduce chronic inflammation by improving your diet. There are also many natural herbs, antioxidants and other natural products you can take as well. None of these have the side effects that NSAIDs have.

Besides medications, there are "natural" things you can do to help relieve depression, such as taking fish oil or eating healthier foods.

As soon as you become pregnant, especially if you have PCOS, please consult with your doctor about the benefits and risks of every pharmaceutical drug you take.

Nakhai-Pour HR et al, Use of antidepressants during pregnancy and the risk of spontaneous abortion, CMAJ. 2010 Jul 13;182(10):1031-7
Nakhai-Pour HR et al, Use of nonaspirin nonsteroidal anti-inflammatory drugs during pregnancy and the risk of spontaneous abortion, CMAJ. 2011 Oct 18;183(15):1713-20.

Related Articles

E-Books to Help You Manage PCOS

Get Answers to your Questions about

  • Fertility
  • Weight Control
  • Hair Loss
  • Stress
  • Unwanted Hair
  • Acne...and more!

and Newsletter

First Name
Email *

Your email is safe with us. We respect your privacy, and you may unsubscribe at any time.

Click Here for More Info

Recent Articles

  1. PCOS, Weight Gain Linked to Hidden Environmental Chemicals

    Sep 24, 17 12:03 AM

    Research shows environmental pollution makes you fatter, and contributes to other PCOS symptoms. A detox program may help.

    Read More

  2. Got PCOS? Try Restoring Your Cycle with Psychotherapy or Hypnosis

    Sep 09, 17 07:06 PM

    PCOS is partly an emotional and mental problem. If you can shift your mindset, you may be able to normalize your cycle.

    Read More

  3. PCOS Success Stories. How other Women Have Managed Polycystic Ovary Syndrome.

    Sep 09, 17 06:25 PM

    Suffering from PCOS or infertility? Other women share their experiences - what worked and what didn't.

    Read More