PCOS and Acanthosis Nigricans (Dark Skin Patches)

It's estimated that approximately 5% of women with PCOS have a condition called "acanthosis nigricans".

It's a skin disorder having darkish, velvety skin in body folds and creases, especially the neck, groin or armpits. Sometimes, the lips, palms, soles of feet, belly button or other areas may be affected. Skin tags are often present.

Acanthosis nigricans usually appears slowly and doesn't cause any symptoms beyond the skin.

Acanthosis nigricans is typically classified into 2 types: benign (not cancerous) and malignant (cancerous).

People with the malignant form of acanthosis nigricans tend to be thin and over 40 years of age, and their eruption is of recent origin. Abdominal adenocarcinoma is the most common cancer associated with malignant acanthosis nigricans.

Most individuals have the benign form and may be very overweight or obese. Some also have chronic diseases such as polycystic ovarian syndrome, Cushing's syndrome or diabetes. Acanthosis nigricans has also been linked to genetic diseases and drug reaction (nicotinic acid, for example).

The presence of acanthosis nigricans is a predictor of abnormal glucose tolerance in women who have PCOS. If this describes you, then you need to change your diet and increase your exercise in order to improve your blood sugar control and normalize your insulin levels.

Insulin Resistance Is a Cause of Acanthosis Nigricans and PCOS

The most common cause would be insulin resistance, or the body's inability to efficiently utilize the hormone insulin. Insulin resistance is also a leading cause of polycystic ovary syndrome.

Obesity can lead to acanthosis nigricans, as can many endocrine disorders such as polycystic ovary syndrome. Acanthosis nigricans is frequently found in people with diabetes.

Some drugs, such as human growth hormone or oral contraceptives, may also contribute to acanthosis nigricans.

People with cancers of the gastrointestinal or genitourinary tracts or with lymphoma may develop acanthosis nigricans.

It is more common among people of African descent.
Treatment

Local treatment of the affected skin is not very effective. However, Retin-A, 15% urea, alpha hydroxyacid, and salicylic acid are some medications that may provide some relief.

If you have polycystic ovary syndrome and acanthosis nigricans, you probably also have insulin resistance and are likely to be overweight. The most effective long term treatment for this combination of symptoms is to improve your diet, get more exercise, reduce chronic stress, and take selected nutritional supplements as indicated.

You can also take medications such as metformin.

A diagnostic workup with your doctor is also advisable to rule out the possibility that a tumor may be involved.

Learn more about acanthosis nigricans here.

Return to PCOS Symptoms Page



Get Answers to your Questions about

  • Fertility
  • Weight Control
  • Hair Loss
  • Stress
  • Unwanted Hair
  • Acne...and more!

FREE PCOS Report
and Newsletter

Your email is safe with us. We respect your privacy, and you may unsubscribe at any time.

Get Answers to Questions about

  • Fertility
  • Weight Control
  • Hair Loss
  • Stress
  • Unwanted Hair
  • Acne...and more!

FREE PCOS Report
and Newsletter

Your email is safe with us. We respect your privacy, and you may unsubscribe at any time.

Click Here for More Info


Recent Articles

  1. 16 Ways PCOS and Health Is Improved with Fish Oil

    Dec 07, 16 11:51 PM

    Omega-3 fish oil helps symptoms of PCOS (polycystic ovarian syndrome), including insulin resistance, heart and liver disease, diabetes, high triglycerides, depression and stress.

    Read More

  2. High anti-Mullerian hormone - Any Ideas?

    Dec 04, 16 07:26 PM

    Thank you for your newsletter! I have found it difficult to find useful, outside-the-box information on PCOS. I'm not a huge researcher because I find

    Read More

  3. PCOS May Be Treated with Aldactone, Flutamide, Propecia, or Proscar

    Dec 04, 16 02:58 PM

    Women with PCOS-related hirsutism, hair loss and acne may be treated with spironolactone (Aldactone), cyproterone acetate, flutamide (Eulexin), or finasteride (Propecia, Proscar).

    Read More